An intravaginal ring that releases the NNRTI MIV-150 reduces SHIV transmission in macaques.

نویسندگان

  • Rachel Singer
  • Paul Mawson
  • Nina Derby
  • Aixa Rodriguez
  • Larisa Kizima
  • Radhika Menon
  • Daniel Goldman
  • Jessica Kenney
  • Meropi Aravantinou
  • Samantha Seidor
  • Agegnehu Gettie
  • James Blanchard
  • Michael Piatak
  • Jeffrey D Lifson
  • José A Fernández-Romero
  • Melissa Robbiani
  • Thomas M Zydowsky
چکیده

Microbicides may prevent HIV and sexually transmitted infections (STIs) in women; however, determining the optimal means of delivery of active pharmaceutical ingredients remains a major challenge. We previously demonstrated that a vaginal gel containing the non-nucleoside reverse transcriptase inhibitor MIV-150 partially protected macaques from SHIV-RT (simian/HIV reverse transcriptase) infection, and the addition of zinc acetate rendered the gel significantly protective. We test the activity of MIV-150 without the addition of zinc acetate when delivered from either ethylene vinyl acetate (EVA) or silicone intravaginal rings (IVRs). MIV-150 was successfully delivered, because it was detected in vaginal fluids and tissues by radioimmunoassay in pharmacokinetic studies. Moreover, EVA IVRs significantly protected macaques from SHIV-RT infection. Our results demonstrate that MIV-150-containing IVRs have the potential to prevent HIV infection and highlight the possible use of IVRs for delivering drugs that block HIV and other STIs.

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عنوان ژورنال:
  • Science translational medicine

دوره 4 150  شماره 

صفحات  -

تاریخ انتشار 2012